Comment Most relevant to me? Mine. (Score 1) 321
Decrypting Rita, the sci-fi comic I write and draw, has certainly been the most relevant to me this year.
It's about a robot lady who's dragged out of her timeline and scattered across four separate realities. And a couple of hive-minds, one of which intends to assimilate the whole Earth. Also of course it's about the other versions of her - a normal lady in the here and now, a dragon living with her elf boyfriend and girlfriend, and a wizard journeying to the center of her world of floating islands. I try to keep it pretty fast-moving and action-packed despite it swerving into "what is reality?" territory now and then, though the page update rate has slowed to a crawl as I deal with fulfilling the Kickstarter I ran for the first collection of it.
Homestuck is the best web comic around, IMHO. Andrew Hussie is consistently pushing the boundaries of what a webcomic "should" "be" and making this crazy pile of transcripts, animgifs, and the occasional game or animation work as a coherent whole.