The most important consideration is the format desired by your publisher. If your publisher wants doc files, you get to use Word.

Any publisher's staff is overworked and underpaid, just like the rest of us. If you make your editor work harder because you won't work to the company's requirements, then they won't work as hard on your book. You want them improving your book, believe me. You don't write as well as you think you do. Nobody does.

Will the publisher try to work with you when you present your manuscript in a bastardized mix of LaTeX and POD? Sure. But you won't make friends. And being friends with your publisher's employees is essential if you want your book to actually appear on bookstore shelves.