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Comment Re:All or nothing (Score 5, Insightful) 83

Doubtful it will be a 'switch' like one thinks about in electronics or logic. It is a complex pathway so there will be plenty of other regulatory and counter regulatory effects. Of interest, is that there are a number of drugs already in trials that work on similar pathways, so it's a bit doubtful that these researchers have found a magic bullet type of thing.

And even if they can shut it off completely in animal studies, it is a long road to developing a useful clinical treatment.

Don't short opium growers just yet.

Medicine

Researchers Discover an "Off Switch" For Pain In the Brain 83

concertina226 writes Scientists working together from several international universities have discovered that it is possible to block a pathway in the brain of animals suffering from neuropathic pain, which could have a huge impact on improving pain relief in humans. So far, the most successful ways to treat chronic pain from a pharmacological point of view are to create drugs that that interact or interfere with various channels in the brain to decrease pain, including adrenergic, opioid and calcium receptors. However, there is another way – a chemical stimulator called adenosine that binds to brain receptors to trigger a biological response. Adenosine has shown potential for killing pain in humans, but so far, no one has managed to harness this pain pathway successfully without causing a myriad of side effects. Led by Dr Daniela Salvemini of SLU, the researchers discovered that by activating the A3 adenosine receptor in the rodents' brains and spinal cords, the receptor was able to prevent or reverse pain from nerve damage (the cause of chronic pain).

Comment Re:The directive does not mention google. (Score 1) 237

The company I work for has a list of "brands we do not advertise" as a result of the agreements we have to buy stuff from the makers of those brands. But when a print ad goes out listing a "Major Name Brand" laundry detergent next to a picture of a big orange jug, everyone still knows its Tide. The oblong yellow box of melting cheese is Velveeta. And a directive to separate search from all the things that help search make money is an attempt to screw Google.

Comment Re:Not humane? (Score 1) 47

"more distributed" means more land use.

No, not it does not. It means integrating them into existing land use, in places where they're not used.

human labor is an astoundingly costly input, even just from an environmental perspective.

Nonsense.

Modernization of food production is the central thing that has raised the standard of living from the stone age to the present day

Bullshit. That's often said but never backed up. The Green Revolution has in fact diminished our ability to produce food without massive energy expenditure. We must go back to a closed cycle in which the crap is reused or we will continue to deplete our topsoil. The best the GR achieved anywhere in the world was delaying starvation, and in some places it may well have caused at least as much as it postponed. Take a look at India to see what's coming for the rest of us.

Comment Re:Then don't sign the contract (Score 3, Insightful) 189

But it sounds like Apple was bankrolling GT for the factory. which means they negotiated some kind of investment budget. Apple probably went through the list, found what sounds like excesses and asked GT if all this was really necessary or if it could be done cheaper. Apparently GT failed to justify the cost, so it was stricken from the final budget. When shit hit the fan it might have been too late to start redesigning and they were already behind schedule and budget with botched batches, GT might not have had the financial muscle to fix it and Apple might be concerned about throwing good money after bad. After all, this is how most terrible investment decisions are made, we're already $500 million down the hole so we need to spend a hundred more to finish it. Then we're already $600 million down the hole so we need to spend a hundred more to finish it and so on. Apple had a reasonable plan B by sticking with Gorilla Glass so they weren't pot commited as they'd say in poker.

Remember, just because GT can point to this and say that's why it failed doesn't mean it'd be a success otherwise as they might have stumbled on the next hurdle too. After all, if the product that did come out okay was that great I'm sure Apple would have been more willing to see it through too, unless they decided it was cheaper to let GT fail and pick up the pieces. I really doubt it's as easy as Apple buying GT's assets, installing a few UPSes in the factory and they're ready to go for the iPhone 6s. Like they say, production at this scale had never been attempted before which generally means you have to expect the unexpected. GT seems to have bet everything on things going according to plan, they gambled and lost. It's pretty cheap to try blaming Apple for their own botched execution, they're a business and don't just throw money around. If they failed to get sufficient investment that's nobody but GT's fault.

Comment Re:In this house we obey the laws of thermodynamic (Score 2) 145

It's not the ambient temperature of air that's key here, it's the ambient temperature of space, which is about 2,7K.

All objects are constantly radiating energy and receiving energy back from other things that are radiating. When two objects in radiative exchange are roughly the same temperature, this balances out. But when one is hotter than the other, the hotter one loses more energy than it takes in, and vice versa. And it's not just a little difference - radiative heat loss is proportional to the absolute temperature to the fourth power, that's a pretty big exponent. So when you're exchanging energy with space, which is so cold that it takes very sensitive instruments to be able to measure *anything*, well, that heat is simply lost.

You can see this effect for yourself by noting how cloudy nights are usually warmer than clear nights. Clouds are cold, but they're not as cold as space!

The effect of the combination of radiation, absorption, and reflection, with different band peaks for each phenomenon, manifests itself in atmospheres as a greenhouse effect (positive or negative) versus the radiative equilibrium temperature.

Comment Re:In this house we obey the laws of thermodynamic (Score 1) 145

This "modulation" happens all the time, few things in this universe are true blackbodies, most prefer to radiate in specific bands. They're apparently using a material that tends to radiate only on one narrow band at regular earth temperatures.

Not sure how much benefit this provides to the building owner, to the point that they'd be willing to cover their building in hafnium-and-silver coated panels, rather than just white paint...

Comment Re:Its just Apple being Apple (Score 0) 189

What kind of surprises me is that Apple doesn't have their own skunkworks R&D for coming up with new technologies like sapphire screens or other key components. They could work out what they wanted and then farm it out to someone who can mass produce it. Sort of like the Bell Labs or IBM labs.

Under Jobs, Apple followed Jobs' vision. Without Jobs, Apple has no vision.

Probably they should have gone with JLG and BeOS instead.

Comment Re:WRONG- it's brittle (Score 3, Informative) 189

Sapphire ***IS*** extremely true scratch resistant (as in the surface atoms resist displacement) because sapphire is BRITTLE.

Well... no. Sapphire is extremely scratch resistant and sapphire is relatively brittle. Just because something is scratch resistant does not mean it has to be brittle. Gorilla glass is, for example, both harder and tougher than normal glass. Diamond is both harder and tougher (iirc) than sapphire.

Comment Re:No clue? (Score 5, Interesting) 237

The whole idea is stupid. What governments should of course be considering instead, if they find biased internet searches so troubling, is to create a government body that provides the same service upon a completely neutral basis.

"Neutral", seriously you want a government imposed Pravda? Or are you just trying to set up such an absurd left wing straw man to get everyone on Google's side? What the EU is generally against is bundling products and services because it hampers competition and creates vertical collusion and hidden costs. Say you buy a car only to find they use IP, warranty terms, secret error codes and such to make sure you only use original parts, authorized service dealers, approved fuel and tires from partners and so on . There's laws curbing such behavior because it's in the consumers' interest that car companies compete on making cars, auto repair companies compete on maintenance and repair and tire manufacturers compete on making car tires. It doesn't mean the government should jump in national everything so everybody gets "fair" maintenance on their cars.

For example, during the first iPhone launch here they tried playing the "exclusive carrier" game bundled with a high monthly cost, but our consumer laws demand you can terminate such a agreement by covering their loss. So those who wanted another carrier would sign up, got their iPhone, insta-canceled, paid for the full price of the phone and was free to sign up with another carrier. That effectively killed it, pretty soon after you could buy it directly with no subscription and sign up with whoever you wanted. And that's how it should be, phone manufacturers compete on phones and carriers compete on being carriers. Companies don't want free markets where prices are low and competition intense, they want dysfunctional markets where they can make huge profits. This is very obvious in software where they want you to buy into the Microsoft stack or the Apple stack or the Google stack. If the bits and pieces were compatible and interchangeable you'd see a lot more competition and many smaller third parties providing a few parts. Bunding is a way for megacorporations to make sure only megacorporations compete.

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