Submission + - Blindness - Restoring Vision with Genetic Therapy
pizzaman100 writes: A clinical trial has begun in the UK to to treat blindness by genetically modifying DNA. The same method has already been used to restore vision to dogs. The treatment works by injecting a genetically modified virus into the retina. The virus attacks the cells in the retina in a beneficial way by inserting good DNA into the cells.
According to the article: Robin Ali at Moorfields Eye Hospital in London and colleagues are treating adults and children with Leber's congenital amaurosis (LCA), caused by an abnormality in the RPE65 gene. This gene is important in recycling retinol, a molecule that helps the retina detect light. People with LCA usually lose vision from infancy. Ali's team are inserting healthy copies of RPE65 into cells in the retina, using a viral vector. Previously, dogs with LCA have had their vision restored in this way, allowing them to walk through a maze for the first time without difficulty.
According to the article: Robin Ali at Moorfields Eye Hospital in London and colleagues are treating adults and children with Leber's congenital amaurosis (LCA), caused by an abnormality in the RPE65 gene. This gene is important in recycling retinol, a molecule that helps the retina detect light. People with LCA usually lose vision from infancy. Ali's team are inserting healthy copies of RPE65 into cells in the retina, using a viral vector. Previously, dogs with LCA have had their vision restored in this way, allowing them to walk through a maze for the first time without difficulty.
