Comment Sure, why not? Learn to use selectors (Score 1) 126
It helps some times, and if you are going to become a good JavaScripter, how much of the effort is really redundant? You'll probably need to learn how to select an element with CSS selectors even if you don't use jQuery. It's clear you eventually won't need jQuery for this, but a) jQuery is a little less verbose b) learning how to use selectors is 90% of learning jQuery.
Granted, you don't need to learn how to write a jQuery plugin anymore, not that would be difficult to learn anyway. Aside from that, what is there? Using plugins: trivial. Using the jQuery's ajax stuff: trivial. Learning to use promises: you need that anyway, learning jQuery's slight differences isn't really a big deal.