Okay, let's set aside for just one brief moment that a goodly part of the science portrayed on the show is just plain wrong, and discuss instead what I think is a much more interesting topic: Trying to take a show that is centered around brilliant people and making it not only acceptable, but very funny to stupid people.
Don't you agree that it is an exercise in futility to make an attempt at incorporating low-brow, "everyman" humor into this show? Let's face it, nobody who is as smart as Sheldon or Leonard are would find any of the humor in the show consistent, let alone funny.
I recall one episode (forgive me for not remembering the title) where Leonard suggests that Sheldon drink plenty of fluids - maybe it was the one when Sheldon got sick right before the trip to Switzerland or something - but in any case his retort was something like "well what else would I drink? Maybe gasses or ionized plasma?"
Someone as smart as Sheldon, especially a theoretical physicist, knows that gasses and ionized plasmas ARE fluids - the obvious mistake here being to imply that the term "fluid" is interchangeable with the term "liquid," when it is not.
I've found the show to be chock full of these kinds of glaring inconsistencies and falsehoods. It leads me to believe that the show's writers either don't really listen to you, or go over the material and change it after you've edited it, or something else. Can you enlighten us?