Viking, Voyager, Galileo, Cassini - these were the so called "Flagship" missions - big, envelope-pushing missions intended to substantially advance our knowledge of the solar system. (MSL is really another, but Mars is special for NASA and so they don't call it that.) They have somewhat fallen out of favor, as they are very expensive and prone to delays and overruns, but it is hard to see how there can be substantial advances, particularly in the outer solar system, without them.
The next mission of this class will, Congress willing, be the Europa-clipper, which is slowly getting to the AO stage. I can hardly wait.