Take your argument of freedom of manufacture to its logical conclusion: several decades from now these technologies allow literally anyone to "print" a biological agent that's more infectious than influenza and deadlier than rabies, with high mutation rates that makes countermeasures difficult to develop, yet designed to preserve it's virulence and deadlines, and with sufficiently long incubation time that by the time it's noticed, it's too late. Or, give it some more time, and anyone can "print" a world-consuming nanotechnological grey goo. Suggesting technological defenses are feasible is a naive failure to recognize a fundamental asymmetry: destruction is far easier than creation, and chaos is thermodynamically favorable. There are only three options for the long term: humanity is destroyed, access to advanced technology is severely limited but for our overlords, or it's allowed but privacy is dead — absolutely — with constant ubiquitous automated monitoring everywhere and of everything. Pick one.