While there are times I wish I had one, my work speaks for itself. Don't get me wrong; life would have been easier and I probably could slack off more (my experience with degree'd IT people) and easily get away with it.
Not having a degree does mean you have to work harder and gain more experience. It helps to have people along your career that can vouch for you as well. I started my first 'corporate' job as a Tech Support rep. Worked there until I became a Senior Systems Engineer (6yr) and then moved onto my current job as an IT Manager by knowing the Owners of this company through my experience with the last. I've also gotten to know many in the healthcare and general technology industry.
Generally; as long as you work hard, know the right people and can easily prove your strengths you should be able to get a job just about anywhere. The more you bullshit the less likely you are to get a job. Most people in the industry that are worth a grain of salt can detect BS a mile away.
He has not acquired a fortune; the fortune has acquired him. -- Bion