Submission + - DNA differences observed between blood and organs (genomeweb.com)
Scrameustache writes: Researcher working on a rare type of aortic abnormality found that the DNA from diseased tissue did not match the DNA from the blood of the same patients on the same gene.
So far it's unclear whether these differences in the blood and aortic tissue are the consequence of RNA editing, which changes the messenger RNA but not the gene, or DNA editing, which involves differences in the gene itself.
Based on the evidence so far, senior author Morris Schweitzer, an endocrinologist and lipidologist with McGill University, believes the differences his team detected resulted from developmental rather than somatic DNA alterations. Such a pattern may not hold true for all genes, he said, but there could be other genes that vary slightly between blood and other tissues.
Based on the evidence so far, senior author Morris Schweitzer, an endocrinologist and lipidologist with McGill University, believes the differences his team detected resulted from developmental rather than somatic DNA alterations. Such a pattern may not hold true for all genes, he said, but there could be other genes that vary slightly between blood and other tissues.
