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Comment Re:Not "thousands" (Score 1) 53

Oh, don't worry, I double-checked Wikipedia too. :) If those were truly multicellular (and the evidence is inconclusive as to whether or not some of them were even cells) then it's very likely they developed it independently. Continuing to quote Wikipedia:

Multicellularity has evolved independently at least 46 times,

...and that's without discussing pluripotency, which is the ability to differentiate various kinds of cells. It's very unlikely that Metazoa separated from Protozoa more than a billion years ago.

(Better luck next round, hero.)

Hardware

Video Used IT Equipment Can Be Worth a Fortune (Video) 79

This is a conversation with Frank Muscarello, CEO and co-founder of MarkiTx, a company that brokers used and rehabbed IT equipment. We're not talking about an iPhone 3 you might sell on craigslist, but enterprise-level items. Cisco. Oracle. IBM mainframes. Racks full of HP or Dell servers. That kind of thing. In 2013 IDC pegged the value of the used IT equipment market at $70 billion, so this is a substantial business. MarkiTx has three main bullet points: *Know what your gear is worth; *Sell with ease at a fair price; and *Buy reliable, refurbished gear. Pricing is the big deal, Frank says. With cars you have Cars.com and Kelley Blue Book. There are similar pricing services for commercial trucks, construction equipment, and nearly anything else a business or government agency might buy or sell used. For computers? Not so much. Worth Monkey calls itself "The blue book for used electronics and more," but it only seems to list popular consumer equipment. I tried looking up several popular Dell PowerEdge servers. No joy. An HTC Sensation phone or an Acer Aspire notebook? Sure. With price ranges based on condition, same as Kelley Blue Book does with cars. Now back to the big iron. A New York bank wants to buy new servers. Their old ones are fully depreciated in the tax sense, and their CTO can show stats saying they are going to suffer from decreasing reliability. So they send out for bids on new hardware. Meanwhile, there's a bank in Goa, India, that is building a server farm on a tight budget. If they can buy used servers from the New York bank, rehabbed and with a warranty, for one-third what they'd cost new, they are going to jump on this deal the same way a small earthmoving operation buys used dump trucks a multinational construction company no longer wants.

In February, 2013 Computerworld ran an article titled A new way to sell used IT equipment about MarkiTx. The main differentiator between MarkiTx and predecessor companies is that this is primarily an information company. It is not eBay, where plenty of commercial IT equipment changes hands, nor is it quite like UK-based Environmental Computer, which deals in used and scrap computer hardware. It is, rather, the vanguard of computer hardware as a commodity; as something you don't care about as long as it runs the software you need it to run, and you can buy it at a good price -- or more and more, Frank notes -- rent a little bit of its capacity in the form of a cloud service, a direction in which an increasing number of business are moving for their computing needs. Even more fun: Let's say you are (or would like to be) a local or regional computer service company and you want to buy or sell or broker a little used hardware. You could use MarkiTx's price information to set both your buy and sell prices, same as a car dealer uses Kelley Blue Book. We seem to be moving into a whole new era of computer sales and resales. MarkiTx is one company making a splash in this market. But there are others, and there are sure to be even more before long. (Alternate video link.)

Comment Re:Too Little Too Late (Score 1) 166

It's not about whether the game is fixed or not, it's about the business's management decisions. Lots of people won't buy EA games, for example, regardless of the quality of the title itself, because of the business's conduct in the past. The simple act of shipping a fixed game doesn't equate to the necessary cultural shift from the developer that would merit returning to the game. It's not as if they've gotten rid of Bobby Kotick as the head of Activision Blizzard, or said they'd commit to a long-term fan-driven model across their titles. It's essentially a boycott.

On top of that, we're talking about rewarding them with more money for what is, at its heart, an old product with some refreshes. Expansion packs and other forms of non-free DLC are only really effective at drawing in consumers when the base product has something the player wants to continue. Many people (myself included) got sick of the repetitive, imbalanced structure of the game a year and a half ago, when it first came out, and we have no desire to relive those memories or anything tightly associated with them. D3 had a breathtakingly uncompelling story; the adventure RPG equivalent of a cookie-cutter save-the-cat blockbuster, only without any character development whatsoever. (Unless you can think of a game with a lamer ending cutscene?) Even without the auction house, crazy elite monsters, terrible loot rates, failure to learn from competitors and clones like the Torchlight and Dungeon Siege series, the total lack of character personalization, and the extensive balance issues, I think the exploitative, sequelitis-infested anti-plot would be enough to keep people away from any continuation of the franchise.

Comment Re:Too Little Too Late (Score 1) 166

I believe the obvious message is "the bridges are burnt," not "we want more crappy games." Publishers may be incredibly, unbelievably stupid, but they are stateful enough to know when they've killed brand trust. It is one of the few things they are indoctrinated in, since they are little more than marketers run amok.

Comment Re:I call BS (Score 1) 71

(Sure, but PacBio in particular is quite new on the market still. Three years ago they were borderline vaporware!)

And, yeah, most serious sequencing projects I've seen do use a mixture of methods, particularly 454 stuff. But I'm sure they'll switch to IonTorrent and PacBio as opportunities allow.

Comment Re:I call BS (Score 3, Informative) 71

63x total coverage with from Illumina hardware using a mixture of paired-end libraries, ranging from 200 bp to a whopping 40 Kbp. I'm pretty sure that's sufficient information to estimate the number of large-scale repetitions. Sequencing projects of species for which there is no good relative to scaffold against are typically much more rigorous than what you'd see in cancer research.

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