There's some reasons this won't work.
EG-- Think of what would happen if you used ComCast's various local networks (the neighborhood branch networks that the cable modems are attached to), and all the VoIP connections that are being shuttled through them, and subtly alter their delivery routes a few hops at a time using the distributed arp poisoning approach above. By the time you get it over comcast's backbone connection, you would be directing a huge bitstream of "Legitimate", "high priority" packets. At the same time, you would be doing the same thing with ATT, TimeWarner Cable, etc... The end goal is to get all of those rivers of traffic to flood into the final network segment via its many backbone connections, fully saturating the segment, and overloading the routers at the destination.
1) It's highly unlikely you're going to have drones on continuous subnets, at least continuous enough to hit a target somewhere across a few networks. Outside of the network edge, where are you going to have an infected node? Once you're outside of the cable modem/VoIP access switches it'll be network aggregation. Good luck having an infected device connected on these switch-router or router-to-router network segments, which are probably all subnetted to allow only a few IP hosts anyways (which are other switches/routers).
2) I would assume ISPs are using static ARP entries in that aggregation layer. But, you never know.
3) At the access layer, many switches are configured to only allow 1 or 2 MAC addresses in a time period. If you suddenly change and dump a new MAC out, your port can be auto-disabled. (see port security)
4) Switches can be configured to monitor the DHCP leases granted by the network's trusted DHCP servers. If your port has an ARP packet come in with a source IP that was not leased out in its ARP messages, the packet is dropped. (see DHCP snooping)