I've got a few issues with this whole thing.
First, since the main complaint against megaupload was they were doing data-deduplication, at what granularity do you need to dedupe before you become infringing?
This is problematic because of #2: DMCA complaints lie. Like, the majority of the time. They keyword search and send takedown requests to files with names they don't like without ever seeing the content. So, if a service dedupes content like that all you need to do is upload something that's popular and name it "Britney Spears #1 hit poop" and get it DMCAd. Troll heaven.
Third, their "Paying pirates" is a bald-faced lie. Putting up content you own and getting paid for it was a way to make money for independants of all stripes - modmakers, musicians, amateur directors, etc. The fact that some people made money with things they didn't own (And don't forget that takedowns were honored, dispite the misleading wording of the indictment.) doesn't change the fact that it had a massively non-infringing use. As for their "evidence", try to find one ISP where employees don't talk about using their bandwidth to download not-entirely-legit content. It's considered a job perk of a fat pipe.
Lastly, The MU takedown had the intended effect. Filesonic died early this morning as well. If you don't own your own hosting, good fucking luck sharing anything you've created with the world. There's a lot of minecraft mods that are just gone now, for instance.