This really depends on your coworkers and what type of work everyone does. If everyone is pretty savvy then you might be OK. No two people use their computer the same way at work though and you'd be surprised how many backwards things people will do as part of their daily work flow.
There aren't many warning pop up boxes to save users from themselves. Are you ready to deal with "I accidentally removed my toolbar" or something equally absurd? Or "Why is it i keep getting a crackling sound when i listen to a youtube video?" Little things that you take for granted that work well on a Windoze box can actually be a pain for average people even in an office environment. Adobe Flash is a pain in the balls randomly on Windoze!
No good deed goes unpunished.