Comment Lift (Score 1) 300
The other problem is lift. When you get to that kind of altitude, you either need to be at orbital speeds (not going to happen) or you need an incredible wingspan relative to mass to get lift from what little atmosphere is available. A third option is some kind of thrust to directly counteract gravity, which would be horribly fuel inefficient. Regardless, you end up with an extremely specialized, hard to fly aircraft like the U2 or SR-71 Blackbird, which has severe limitations in "normal" flight characteristics just so it can fly high and fast. Plus you're not going to be able to scale those kinds of specialized designs up from transporting just one or two people to an entire load of people to achieve the passenger volume an airline requires.