Not enough information, you'll have something like failure possibilities in: the physical server, the VMs, the SQL Server instance, the Hard Disks, the hypervisor, the POS application, the queries, the backup process, the restore process, etc. All of them have tried and trusted solutions, but you need to establish what you're tackling first.
If the answer is 'all of them' and you don't want to break it down and think about each item then you're better off pushing the problem out to an expert to manage it for you, you can take a range of hosted solutions or get someone to remote or local manage your infrastructure for you.