Not this Luddite bullshit again. When I'm on the road, I'm on my way to a destination. When it's for work, I don't care about new places, I just want to get my appointment via the most efficient route. When I'm on vacation, there's a bit more leeway but I still have a destination to get to. At the end of a long journey, I no longer care about the scenery and just want to get to my hotel or campsite already.
The cost of making a mistake is high in lost time and aggravation. Without GPS I'd have to resort to maps, and have you ever driven solo while navigating from a map? You end up either a menace on the road, or having to stop to consult the bloody map every 5 minutes. Not to mention having to buy the map in the first place.
So if you enjoy getting lost, fine. But stop whining about people using GPS.