Comment Can't choose just one... (Score 1) 321
I can't decide on a single best webcomic, so that would be either Subnormality, Wapsi Square or Sequential Art.
Funniest would be either Girls With Slingshots, Two Guys and Guy or Shit Happens! (yeah, sorry - it's in German only).
Best art is again either Subnormality, Zebra Girl or Power Nap.
And the most relevant comic to me in 2012 definitely was Wapsi Square, the first thing I check in the morning after getting up (also going by the amount of prints I bought)...
Honorable mentions: Hobotopia, Bear Nuts, Modest Medusa, Flaky Pastry and Hate Farm.
np: Louie Austen - Never & Ever (What A Comeback!)