When I started to have wrist tendon pains about 10 years ago - I got a Microsoft ergonomic - which helped a lot - and I used that for years. However, through use of that keyboard, I also started to have pain again. Part of it was the non-adjustable nature of that keyboard, and the other part of that was the short compression rubber dome switches it used - which was destructive to my fingers and caused me to slow down and use a lighter touch (I tend to pound the keyboard when typing fast due to learning to touch type on a manual typewriter back in the day, and then a number of years of buckling spring style keyboards in between that and the commoditization of computers and keyboards that emerged in the 90s).
Today I have two Kinesis Maxims (one for work, one for home), and I love the way it adjusts - three different 'tent' levels, and fully adjustable angle spacing. Even as good as that is, I still have an old IBM buckling spring keyboard (from an old RS6000 - not a model M - but identical for all intents and purposes), and recently purchased a Corsair gaming keyboard with no number pad (I never use the keypad on 101 keyboards anyway - always type my numbers using the number keys at the top) - which itself uses Cherry Red key switches. Not quite as clicky as the buckling spring - but very nice on my fingers when compared to the pseudo mechanical/dome switches on the Maxim. So when working on different machines, I get different experiences.
For me, the key to healthy wrists and hands as a typist is to mix things up - use more than one type of keyboard. Don't get stuck in a rut.