I'm left handed and I'm accustomed to having to play some games that were made for right handers anyway. I mean, the location of the D-Pad on a NDS (as well as many other gaming controllers) is basically easier for a right hander to play. I still enjoy using / playing it.

I guess I've just adjusted to living in a (mostly) right-hander's world.

I've used bluetooth mice and keyboards at work and home. It's nice if the computer already has a bluetooth adapter as they don't require an extra port. In addition, the bluetooth has better range, so it's nice for a conference room where the computer is far from the keyboard & mouse.

However, for most applications, the negatives outweigh the positives.

Compared to the IR/RF counterparts, bluetooth devices are slow to respond. This is because of power management. The bluetooth devices consume more power, so they aggressively go into power-down modes to increase battery life. As a result, they take extra time to come out of the low-power modes and that's annoying, bordering unusable.

In addition, the fact that bluetooth requires an extra pairing process, when the device becomes unpaired it takes extra steps to restore it. Devices become unpaired when you push the connect buttons on the bottom of the device. This happens a lot when users think that the device isn't working (because it's slow to respond, see above).

These 2 issues result in a worse overall user experience.