HR wants 10 years experience in something that was invented 5 years ago.
Yeah we've all see that but HR usually just parrots what the hiring manager tells them.
If you have bigger-picture skills, you might be tempted to think for yourself.
The problem with having a generalist skill set is that no one at a large enterprise will know what to do with you. Generally a large enterprise will want someone with deep domain expertise in a narrow field. And that makes sense because they have a specific task and it is comparatively easy to evaluate experience versus ability.
I have the skill set of a generalist. I'm have an engineering degree and a business degree and I'm also a certified accountant. I'm rather competent in a variety of skills though if you look hard enough you can usually find someone marginally better at any one of them if you don't need the other talents I possess. I have worked in diverse industries, everything from manufacturing to health care to auctions to retail. I've consulted, owned several businesses and spent many years doing hard core engineering analytics (statistical stuff mostly) for big manufacturing companies. I'm competent in process engineering, product design, production management, statistics, accounting, finance, HR and some areas of IT. When I apply for jobs I generally have little problem convincing the interviewer that I'm pretty smart but they then usually become concerned that I'm either overqualified OR that I will get bored and leave OR they think that I don't have enough experience in the little niche they are hiring for even though I generally could handle it pretty easily.
Generalist skill sets are usually most valuable in smaller companies which cannot afford to have specialists. That's why I run a small manufacturing company rather than working as a minion in a much larger one.