Comment Type 2 diabetes distinction not so clear (Score 4, Informative) 92
Genome-wide association study (GWAS) results for Type 2 diabetes suggest a much larger footprint for islet cell dysfunction in T2D than previously thought. While the "insulin resistance" paradigm still works, we've had to adapt our model to include the more disordered insulin secretion indicated by these results. This is why unbiased and hypothesis-free research methods like GWAS are so powerful -- they aren't dependent on our preconceived notions of how things "should" be.
A nice review reference: Herder et al. Eur J Clin Invest. 2011;41(6):679-92.