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Comment Re:False positives anyone? (Score 1) 281

First, you got the mass wrong. For that formula, the monoisotopic mass should be about 285.1365. Second, if you want the answer to the differentiation between morphine and peperine, check the fragmentation spectra in this link (http://metlin.scripps.edu/metabo_info.php?molid=499) vs this link (http://metlin.scripps.edu/metabo_info.php?molid=43568). That was covered in the article.

Comment Re:1000 days (Score 5, Interesting) 77

The last time I saw a presentation on brain interface technology was almost a year ago, so I'm not 100% current either, but the current state of the art isn't that great.

The fundamental problem is that the brain/hardware interface breaks down with time. In simple terms, it looks like the extremely soft brain tissue doesn't stand up to being in hard contact with the rigid electrodes (there's a nice picture in the article: they look like meat tenderizers). In the long run, there is formation of a buffer zone of unusable tissue between viable brain matter and the electrodes which blocks the signal. This is an area of substantial research: trying to build nanomaterials that serve as a good physical buffer between the brain and electrode, which is a non-trivial problem. Success in this goal can directly lead to longer-lived devices.

So when they say

no evidence has emerged of any fundamental incompatibility between the sensor and the brain

that's not entirely honest. Yes, their sensor still works fine but they still need to adapt it to be more brain-compatible. My personal guess is that this one patient just happens to have a lucky brain composition/response.

Comment Re:Care about roundoff? You better know types. (Score 1) 119

Well, if that's the question at hand, then I prefer "5" and "2" to be integers. Perhaps this is naive, but my assumption is that standard will cause mistaken use of the wrong type to be catastrophically wrong, and hence easier to detect. An accidental float will happily churn through your calculations through many steps before you run into a situation where it causes a problem, but 5/2=2 gives you dramatic errors very quickly if you're thinking floats.

Comment Re:In Defense of Matlab (Score 1) 119

Graphics: Matlab has the most feature-rich and usable graphical environment of any of its would-be competitors, none of which do 3D well.

I'm interpreting that to say that Matlab does a better job at 3D than the competitors, which is exactly the opposite of my experiences.

I work 100% in Python/Scipy/etc, and my brother does 100% Matlab. He had to come to me for suggestions when Matlab failed to handle visualization of his extremely large 3D datasets (I can't comment on whether he really had exhausted Matlab's functionality for that purpose). Although it's true that Matplotlib has pretty poor 3D support, Python gives you many more avenues: Blender+Python actually gave incredibly good performance for an interactive data environment, although it certainly wasn't designed for it. And VTK will give you anything you want, if you're prepared to put in the time.

Comment Care about roundoff? You better know types. (Score 1) 119

Isn't it fair to say that if you're worried about roundoff noise in repeated calculations, you've passed the point from being just a scientist to a someone who should be concerned with general programming theory and conventions, and hence at least familiar and comfortable with notation that denotes type?

My introduction to IEEE 754 was brought about via Python, when my chemistry kinetic simulations weren't running right (many millions of iterations, scaling factors with huge and tiny exponents). Understanding and fixing that problem took an hour or two, which far overshadowed the minute-long pause when I first found that 5/2 = 2.

In the end, the benefits of having the power of a real programming environment far outstrip the very small entry barrier. I personally feel that in the modern world you have no business calling yourself a scientist of any kind unless you can write a basic data manipulation script (parse and write a flatfile csv/tabs/CRLF etc) in some language of your choice. Massive quantities of data and meta-analyses are now the norm, making manual transcription or even copy/paste a thing of the past, and it is not acceptable to be hobbled by the feature set of existing software.

Comment Re:Well put. (Score 1) 263

If I remember correctly, the Celera data was also more incomplete than the public data. Both projects announced "completion" long before the sequencing was truly complete: genetics has a long tail of data that is more and more difficult to collect, and this long tail was ignored when they said "done". I'm not even sure if it's 100% finished today, but just from memory I think that the public project had a better coverage of the difficult regions compared to Celera.

Comment Re:Conversely (Score 1) 263

I have a bad feeling that this ruling will just shift the focus of patents, without changing their effective targets.

If a kit for diagnosis etc can be patented, the net result is unchanged: the knowledge remains locked-down under the control of the patent-holder. While this wouldn't be a huge problem if the generation of a detection kit was a novel work worthy of protection, the reality is that genetics as a field is a rigorously predictable, formulaic, and mathematical study.

The techniques for working with genetics are very well-understood, and it will likely be a computer algorithm (and not a new one) that designs the tools (DNA primers etc) for performing a particular diagnostic test. Why should that be patentable? At best, it certainly isn't non-obvious, and I would argue that when a machine (which you didn't invent) is designing your invention, you certainly shouldn't be able to claim it as your own!

Of course, there should be room for patenting truly new genetic tools, such as a new type of DNA-binding fluorescent probe, but such inventions come around once or twice a year. The hundreds or thousands of unique gene-detection methods developed per year which use that new tool should not be patentable.

Comment ridiculous, but useful (Score 1) 33

With just a few modifications, that would be perfect for feeding my cat.

She tends to eat so rapidly that she makes herself sick, but the Food Lift could drop the food a little at a time into a bowl over the course of a few hours.

If it weren't $100 CAD, I'd have ordered one already.

Comment Re:Bubby? Is that you? (Score 2, Insightful) 859

If they have paid their dues, and they are fully rehabilitated, then why does it matter if they are mentioned by name? After all, they're just normal citizens again.

Clearly there is a disconnect between the theory of rehabilitation and what the public considers to be sufficient stigma for past offenders

Comment Re:radar accuracy coverup (Score 1) 369

The angular accuracy is very poor. It's not designed to pick out just one vehicle from a group.

The ones with which I have some familiarity are designed to report back multiple signals: the fastest signal detected within the spread of the radar, and the largest. So theoretically they can get a signal off one vehicle traveling very fast through traffic, but if you are always traveling slower than people around you, your car will never be reported to the officer.

Comment Re:ion bridges cost? Consumable? (Score 2, Insightful) 128

More important than the cost is the question of effectiveness.

In their diagram, they have this schematic in the critical location:

[Salt water]<----(+)----[Brine]----(-)----->[Salt water]

Chemically, that "equation" just doesn't balance without an input of energy.  It doesn't matter what kind of "ion bridges" they put into place between the brine and salt water reservoirs, or what the concentration of salt exists in the brine or salt water, it will require some energy to offset the entropy increase.

It's possible that they have some active system in place in the bridges, but it's going to take some kind of energy input which is missing from their explanation.

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