I think the aluminum is just the cheap way to increase the fuel economuy. The basic problem with a truck is the aerodynamics and the engine. The aerodynamics are always going to suck, and there is little that can be done about that. The engine, OTOH, can be adjusted.
Right now most trucks are powered assuming that they are going to be carrying a significant load, and that consumers are going to be expect a good performance with that load. The result of this, and the reason many like trucks, is that when they are not loaded they are overpowered and therefore can achieve a great speed. That many people buy trucks for speed and not load is indicated by the number of automatics that are sold.
This need not be the case. We had an old Toyota pickup and it was a four cylinder 100 horse power r siries engine. When loaded it was slow, but like most people I did not drive it loaded all the time. But it was a working truck. We had a big chevy truck as well for work around the farm. Fords engines are not inefficient, at around 50 horsepower per cylinder. The point is that most people are driving around in a six cylinder truck wasting gas when what they need is 4 cylinder. It can be significant. In they city my six cylinder car get 16 MPG while my 4 cylinder car, just a fast, gets over 20.
That old Toyota was also significantly lighter/smaller than most full size pickups are today. The tiny truck went out of vogue in the US for reasons unknown to me. The smallest thing I know of on the market in the US truck-wise currently is the Nissan Frontier, and it's not exactly small.
Weight is the bane of almost everything performance wise, and everything efficiency wise. Less weight means less power required to change velocity. This could (not necessarily should or will) translate into smaller engines, and lighter running gear and brakes, which will also cause more weight loss.