Why deal with dust at all? Put your scope in space.
The temperature extremes are much worse on the moon - close to absolute zero to hundreds of K if my memory serves right . In space, you just put your scope at L2 or Earth-trailing, build a passive solar shield (or use a cryopump if you need really low temps), and point it away from the sun. Voila, constant temperature and 100% duty cycle. Put your scope in space.
There's also the fact that during the two weeks of duty cycle where you can operate the scope, you don't have solar power, so you have to have some way of storing energy. A telescope in space just uses solar panels and gets power 24/7. You'll have to cool your electronics half the time, and heat them the other half, so again, power, and storage. Go ahead, say nuclear. My understanding is that the moon has very few heavy elements, so all that has to come from Earth. So add a nuclear reactor, RTG, or batteries to your expenses.
Telescopes on the moon have to have pointing mechanisms, and the moon has gravity, so it's more mechanically complex (dust, vacuum). Telescopes in space have reaction wheels and thrusters to control pointing. No dust, and also few moving parts in vacuum. Much simpler. Put your telescope in space.
That is, in fact, why we are putting our telescopes out at L2 or Earth-trailing. Hubble would have been there had it not been for the mandate that it ride the shuttle. Have you noticed that we're not putting telescopes in Earth orbit anymore? It's not because we don't have the shuttle. It's because Earth orbit is sub-optimal, and not just a little bit.
As far as comparing astronomy on the moon to astronomy on Earth, well, Earth has a lot of advantages for telescopes, and that's why there are lot more of them here on Earth than there are in space. Not least that you can breath the atmosphere and find cheap places to sleep and have grad students pull the late night shifts. There are of course disadvantages, and you could never have JWST on the ground, but the moon is just not a great place for telescopes. I'm not entirely talking out of my ass here. I've sat in the rooms where these tradeoffs were made, and the moon gets put on the list. Then we start ranking. The moon ranks low in performance (duty cycle, power), high in cost (humans in space suits have to build it, everything has to be shipped from Earth), and high in risk (you have to ask why, srsly?). Then by the wonders of Excel, the moon drops to the bottom of the rankings.
But it is considered.
That's even assuming we had the capability to build a telescope on the moon. Which would be insanely expensive. Humans building telescopes, launchable or not, where they can breathe is always going to be way cheaper than building them on the moon.
Care to link to any peer-reviewed documentation that shows the abundance of He3, or any other interesting mine-able elements on the moon? I am ignorant of the geology of the moon, so if there's evidence that there are mine-able elements on the moon (including He3), I'd be happy to have my ignorance lessened.
You haven't really addressed the question of you know, actually having a working fusion reaction that needs He3. We don't. And probably won't any time soon. What are the economics of mining something we don't yet need and is difficult to store?