Yeah - same problem - of about nine or ten systems that I've tried it on (up to snv_133), all of them have at least one hardware problem.
eg from my memory
NIC drivers (Broadcom, Even Intel)
W/LAN drivers (Atheros for instance)
Display driver support (not just VESA!)
HW RAID drivers (Compaq, Promise)
AHCI drivers (including NCQ and hot plug support (slated to fix in snv 135)
AMD PhenomII support (fixed now since snv 126)
and I've had issues with the install (eg installation from USB CDROM)
However, saying all this, the journey is worthwhile - some features really are fantastic - especially together:
ZFS + snapshots + dedupe + Virtualbox VMs.
YMMV