immune system phylogeny (Score 3, Informative)

Reptiles have immune systems which work for them. They are cold blooded as was mentioned above. Reptiles (in general) have specialized cells which do phagocytosis (even very primitive organisms have this), lymphoid tissue (gut-associated etc) but not lymph nodes, lyphocytes differentiated into B cells and T cells. What they don't have is the variety of immunoglobulin classes that mammals have. ie Their antibody is IgM-like and IgG-like (IgY), but not IgD, IgE and class switching is either slow or non-existent. Birds were the first (phylogenetically) to exhibit lymph nodes and multiple Ig classes, and class switching. Furthermore reptiles don't seem to be able to do the memory (amnestic response) very well. To say that the reptile system is better (or as good as) the mammalian system is non-sensical. They both work have worked to keep species alive for many millions of years and they both continue to evolve. The key is that they work for each in their own envirnmoment. The immune system of a cold blooded animal is by necessity different from a warm blooded animal because bacteria have adapted to grown so much faster at warmer temperatures. If the immune system cannot respond rapidly (ie memory response) then that individual dies. If you look at the evolution of the immune response it appears to have taken several leaps rather than evolving gradually and steadily. These events coincide with changes which could alter the microbiological pressure on animal species. (see the Silurian period and the development of immunoglobulin and T-cell receptors, also the important RAG 1 and RAG2 genes). If reptiles were evolving into birds and there was a change from cold-blooded to warm-blooded at the same time you would expect to see a shift in the immune system capabilities --- and we do. Insects, while vectors of disease likely had little to do with this shift (Achem's razor) http://www2.ncseweb.org/kvd/exhibits/immune/immune_evo_annotated_bib.html