Though I wonder how Europa Universalis would do it.
My guess is that Russia would form and Kebab would start gobbling up the Balkans. A fractured mess of power would persist in the HRE while Castile inherits Burgundy. England would sit around and not do much except colonize, sip tea, and munch on carpets I mean crumpets. Consequently, Poland would do jack and shit and remain split from Lithuania.
Meanwhile Ming explodes like usual and in an uncommon strange turn of events Japan fails to unite and instead you only see the Tosokawas.