Superbugs, environmental destruction, weakening skeletons, and other assorted genetic 'artificial selection' weakening agents.
For the sake of our short term comforts have we doomed the human species to a genetic inferiority and environmental destruction that could appear to conform to the idea that the candle which burns twice as bright only burns half as long?
In the long term perspective, will the trades have been worth it?
Or it doesn't matter because the universe is far too large to make finding another home practical while this one will have its' oceans boiled away in a billion years?