Comment Re:Got ED? (Score 1) 63
woah, you're totally right. my professor screwed that one up. we were taught that PDE5 cleaves both cAMP and cGMP, but it looks like only PDE1, 2, and 3 cleave both.
the downstream effects would be almost identical though. both cAMP and cGMP cause myosin light chain kinase to be phosphorylated by their respective kinases (PKA and PKG), leading to lower myosin activity and thus relaxation.
nice catch!
the downstream effects would be almost identical though. both cAMP and cGMP cause myosin light chain kinase to be phosphorylated by their respective kinases (PKA and PKG), leading to lower myosin activity and thus relaxation.
nice catch!