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Comment Re:So which drug company is going to buy the (Score 1) 216

(No worries about knowledge level. We're all here to learn, and I'm probably wrong about somethings.)

So, HIV goes latent, so there is effectively no virus. There is nothing for the drug to kill. When HIV goes back into the lytic cycle, you have to have the drug there to kill the virus, but you don't know when HIV goes back to lytic; it can be 2 weeks or 2 decades. You would have to keep the patient on the drug during this whole time or at least keep monitoring the patient and giving them the drug whenever it flares up.

(That's the simplified version. The more complicated version involves HIV never really going latent in the lymphoid organs, slowly infecting more and more CD4 cells, leading to AIDS. It could be that if this drug can get into the lymphoid tissues, you can reduce the viral load inside to make them long-term non-progressors, but that's more complicated.)

Comment Re:So which drug company is going to buy the (Score 1) 216

The RNA from HIV is retro-transcribed into DNA which is integrated into the host cell genome. It can become latent where it does not actively replicate virus. That's why HIV patients can live so long. Something then later triggers the lytic phase where the viral replication resumes, eventually leading to AIDS.

An agent that kills HIV will remove HIV from your system, but the latent virus DNA inside cells remain undetected and cannot be removed.

Comment Re:So which drug company is going to buy the (Score 3, Informative) 216

Even if you can kill the HIV virus, you still wouldn't have a cure.

HIV is a retrovirus. It becomes part of the infected cell's genome. Any agent that kills the virus can suppress symptoms/disease but not cure people who are already infected.

P.S. Please take off your tin-foil hat. The glare is quite annoying.

Comment Re:$225,000 (Score 3, Informative) 216

The 400x part is usually meaningless. It's just 40x objective and a 10x eye piece. What actually matters is the resolution.

Resolution can be improved by things like deconvolution as used in TFS, but that's still relatively low. You can easily start flirting with 7 digit figures when you use confocal microscopy and variations of laser excitation. See: http://en.wikipedia.org/wiki/Confocal_microscopy

Comment Cheap microscope (Score 4, Insightful) 216

As a biologist, I have no idea why they're making such a big deal of it being a $225,000 deconvolution microscope. It's cheap compared with what most institutions have. Besides which is the fact that the microscope used isn't interesting. Any high(ish) resolution fluorescent microscope would have given you the same data. The interesting part is this TRIM5a. Let's see what happens with recombinant TRIM5a in animal studies.

Science

Submission + - Researchers zero in on protein that destroys HIV (physorg.com)

Julie188 writes: Using a $225,000 microscope, researchers have identified the key components of a protein called TRIM5a that destroys HIV in rhesus monkeys. The finding could lead to new TRIM5a-based treatments that would knock out HIV in humans, said senior researcher Edward M. Campbell, PhD, of Loyola University Health System.
Space

Submission + - SpaceX completes Dragon parachute test (spacex.com)

mattclar writes: SpaceX just released footage and pictures of last weeks dragon parachute drop test. Using an eriksson sky-crane the dragon capsule was carried to 14,000feet then released. After a few seconds of freefall the drouge chutes appeared followed by the main chutes. The test concluded with a gentle touchdown within the target area to conclude a test described by SpaceX as "100% successful".

Submission + - ISP to prioritise gaming traffic (pcpro.co.uk) 1

nk497 writes: A UK ISP is now offering a broadband package just for gamers, which will prioritise their traffic to give them an edge over rival players. Demon Internet has also set up direct networks with gaming companies to boost speeds, and is promising lower latency and a higher usage cap than standard packages. "Looking at the usage of gamers, it's actually more akin to a small business," the company said. While paying to get specific content streamed more quickly may worry net neutrality campaigners, Demon says it has enough capacity for its own customers and that's who it's looking out for.

Submission + - New Images Reveal That the Moon is Shrinking (gizmag.com)

Zothecula writes: The moon is shrinking according to a team analyzing new images from NASA’s Lunar Reconnaissance Orbiter (LRO). The images reveal previously unknown cliffs, called lobate scarbs. These are thrust faults that occur primarily in the lunar highlands that indicate the moon shrank globally in the geologically recent past and might still be shrinking today. Although they were first recognized in photographs taken near the moon's equator by the panoramic cameras flown on the Apollo 15, 16 and 17 missions, the fourteen previously unknown lobate scarbs revealed by the very high resolution images taken by the LRO camera indicate that the thrust faults are globally distributed and not clustered near the moon’s equator.
Microsoft

Submission + - Want Windows 7 to support ISO Mount, Vote for it

An anonymous reader writes: Just about everyone including Microsoft uses ISO files. As popular as ISO files are I still have to download software for every PC I own to mount an ISO image. With each release of windows I think this is the year they will include the option to mount a drive in their OS. Searching for the latest freeware I stumbeled upon a vote at the MS connect site to add this feature to Windows 7. I am hoping the slashdot community can make this happen.
http://connect.microsoft.com/WindowsServerFeedback/feedback/details/351231/mount-iso-files
Oracle

Submission + - Java Developer: Oracle-Google Spat About Ego

An anonymous reader writes: The father of Java programming language James A. Gosling has derided Oracle's lawsuit against Google, citing ego, money and power as underlying motivation. In a blog entry, James Gosling commented on Oracle's lawsuit saying, "Oracle finally filed a lawsuit against Google. Not a big surprise." He revealed that after Oracle acquired Sun Microsystems it grilled Sun employees over the patent issues between Sun and Google during the integration process. Gosling said he could see "the Oracle lawyer's eyes sparkle".

Comment Re:Swiss cheese (Score 3, Informative) 324

Instead of indicting everyone under the sun, let's do something to fix it instead of tossing people in jail. Many people contributed a little, like Murder on the Orient Express. In the end, the ultimate responsibility rested on the Pilot-in-Command who paid the price for his mistakes. Let's learn from it instead.

1. Revise procedures so that the PNF (Pilot-Not-Flying) visually confirms the flap & slats indicator instead of just reading it to the PF (Pilot Flying)

2. Design future systems such that the take-off config warning isn't on the same circuit breaker as the Total-Air-Temp sensor. (I'm a recreational pilot, not an engineer, so I don't know if there's a valid reason for them to be on the same circuit.) Also, have an EICAS warning when the take-off-config alarm is disabled.

3. Have the engineers remind the pilots / placard the cockpit to remind them that the take-off-config alarm is disabled.

4. Flapless take-off attempts leading to accidents are not a new thing to airplanes. Further training seems to be required, especially as the small aircraft we all initially learn in will take off without flaps.

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