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Comment Re:Which world? The cancer causing 1 or the cure 1 (Score 1) 18

The threat of any of an offtarget gene edit causing cancer is highly unlikely, but possible. The FDA in Dec.2023, for the first time, approved infusion with CRISPR edited cells as a treatment for sickle cell anemia. The way that works is .. they take some of your blood .. select certain type of stem cells, modify them, and then put them back in you. The reason that approach is safer is because we can check copies of the edited cells to make sure they haven't gotten potentially cancerous mutations. However, I don't believe CRISPR is yet ready for in-vivo (in the body, in a live person) clinical use (and I've worked on/with CRISPR tech for a while now btw fyi). A cell has many features that either block (aka tumor suppressor) or (if over-activated) cause cancer (oncogene). If CRISPR lands off-target on a tumor suppressor, it can enable the cell to become a cancer cell. If the DNA edit happens in the right spot near an oncogene (such as LMO2), it can inadvertently activate it. So off-target is dangerous. But forget off-target, .. even when it lands on-target there's still risks of triggering genome rearrangements (note: CRISPR base editors are not really susceptible to this). We can definitely fix these issues, but it will take time and sustained effort. CRISPR is barely 12 years old. Think of how long it took to make air travel safe, and that was with strong investment.

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