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Comment Re:What the hell? (Score 4, Informative) 646

The argument against fructose has to do with the way the GLUT transporters are regulated. Glucose uptake into the liver is regulated by insulin mediated GLUT4 translocation and GK etc preventing too much of it from going into the liver and getting converted to FA/VLDL and so forth. Fructose can only be metabolised in the liver (unlike glucose) and its uptake into the liver is not insulin mediated as it is transported in by GLUT2.

On the other hand, you could make the argument that sucrose is at least half as bad as fructose since it has about half amount of fructose by weight but fructose is sweeter than sucrose by weight so if one uses the proper proportion it isn't that much worse..

Comment Re:Ever done business in China? (Score 1) 338

Well, evidently you have never published, or if you have, you have never run a larger (multi-pub) project. In this case, you'd publish and then proceed to do the background checks. If the background checks fail, you can publish those as well. If your original research turns out fine, you tack on some additional (original) research and publish that.

Also, given that it worked in a single case, you are evidently on to something. Ergo, checking again is, at this point, a waste of time. You share your findings with the world, and then have other people run with it as well.

More on-topic: I have seen a lot of Chinese, and more generally Asian, papers in my field... but not one of them is original. Also, doubtful results do pass by from time to time (although verifying this is hard, when it comes to sattelite observations there's no doing it twice). It seems that Chinese scholars (based on the ones I know and the research I see) are more concerned with quantity, as it improves your scholarly standing very directly, than with quality. So reproducing research (in my field: doing data assimilation on soil moisture for the umphteenth time) is a quick and easy way to get this.

The problem is exacerbated by american academic institutions, institutions are wholly dependent on getting major grants (or really the overhead money) and have publishing requirements for tenure track faculty. When it is as blatant as publish 25 (or similar) number of publications in 4 years, the rational thing to do is exactly this. Reproduce research / do application work to make sure that arbitrary number is cleared within the alloted time frame.

Comment Recent example Keith Baggerly vs Duke Clin. Trials (Score 1) 505

If you ever get a chance take a look at some of Baggerly's (MD Anderson / bioinformatics/stats) analysis of the number of rather embarrassing mistakes were used in developing genomic biomarkers used for a clinical trial at Duke. He has been giving talks around at stats conferences (and pharma's about this), its one of the best talks i've heard in recent years. But what it boils down to is the analysis (and input) programs used by Duke had a series of fundamental mistakes in it causes the results to be incorrect leading to an incorrect conclusions which unfortunately lead to a series of clinical trials which certainly should not have happened. After Baggerly attempted to respond negatively to the original series of articles being posted he reposted in a stats journal and basically got the clinical trial shut down. For slashdot readers, one of the rather many egregious mistakes here was the analysis program used has in its instructions the need for a header line, the input the Duke researchers used did not include a header line causing a shift in the results with regards to their input. My understanding is nature medicine refused to publish baggerlies initial correspondence with full details as it was "too negative" so he published in a stats journal which then got the critical coverage to shut everything down..

Here are some random links

Here is the original Potti genomics article:
http://www.nature.com/nm/journal/v12/n11/abs/nm1491.html

Here is one of the baggerly nature medicine letters describing what is wrong in summarized form:

http://www.nature.com/nm/journal/v13/n11/full/nm1107-1276b.html

here is the halt of the trials :

http://cancerletter.com/tcl-blog/copy108_of_whats-going-on-with-nih

http://cancerletter.com/tcl-blog/copy111_of_whats-going-on-with-nih

Math

Man Uses Drake Equation To Explain Girlfriend Woes 538

artemis67 writes "A man studying in London has taken a mathematical equation that predicts the possibility of alien life in the universe to explain why he can't find a girlfriend. Peter Backus, a native of Seattle and PhD candidate and Teaching Fellow in the Department of Economics at the University of Warwick, near London, in his paper, 'Why I don't have a girlfriend: An application of the Drake Equation to love in the UK,' used math to estimate the number of potential girlfriends in the UK. In describing the paper on the university Web site he wrote 'the results are not encouraging. The probability of finding love in the UK is only about 100 times better than the probability of finding intelligent life in our galaxy.'"
Image

Surgeon Makes Tutorial DVD For Conscious Open-Heart Surgery Screenshot-sm 170

Lanxon writes "Swaroup Anand, 23, from Bangalore, was fully conscious as he underwent open-heart surgery. An epidural to the neck, administered at the city’s Wockhardt Hospital, numbed his body during the procedure. Dr Vivek Jawali pioneered the technique ten years ago and has recently released a tutorial on DVD, which gives a step-by-step guide to the procedure for other surgeons to watch and learn from."
Education

Ocean-Crossing Dragonflies Discovered 95

grrlscientist writes "While living and working as a marine biologist in Maldives, Charles Anderson noticed sudden explosions of dragonflies at certain times of year. He explains how he carefully tracked the path of a plain, little dragonfly called the Globe Skimmer, Pantala flavescens, only to discover that it had the longest migratory journey of any insect in the world."
Mars

Mars Images Reveal Evidence of Ancient Lakes 128

Matt_dk writes "Spectacular satellite images suggest that Mars was warm enough to sustain lakes three billion years ago, a period that was previously thought to be too cold and arid to sustain water on the surface, according to research published today in the journal Geology. Earlier research had suggested that Mars had a warm and wet early history but that between 4 billion and 3.8 billion years ago, before the Hesperian Epoch, the planet lost most of its atmosphere and became cold and dry. In the new study, the researchers analysed detailed images from NASA’s Mars Reconnaissance Orbiter, which is currently circling the red planet, and concluded that there were later episodes where Mars experienced warm and wet periods."
Media

3D Blu-ray Spec Finalized, PS3 Supported 157

Lucas123 writes "The Blu-ray Disc Association announced today that it has finalized the specification for Blu-ray 3-D discs. The market for 3-D, which includes 3-D enabled televisions, is expected to be $15.8 billion by 2015. Blu-ray 3-D will create a full 1080p resolution image for both eyes using MPEG4-MVC format. Even though two hi-def images are produced, the overhead is typically only 50% compared to equivalent 2D content. The spec also allows PS3 game consoles to play Blu-ray 3-D content. 'The specification also incorporates enhanced graphic features for 3D. These features provide a new experience for users, enabling navigation using 3D graphic menus and displaying 3D subtitles positioned in 3D video.'"
Image

The Perfect Way To Slice a Pizza Screenshot-sm 282

iamapizza writes "New Scientist reports on the quest of two math boffins for the perfect way to slice a pizza. It's an interesting and in-depth article; 'The problem that bothered them was this. Suppose the harried waiter cuts the pizza off-center, but with all the edge-to-edge cuts crossing at a single point, and with the same angle between adjacent cuts. The off-center cuts mean the slices will not all be the same size, so if two people take turns to take neighboring slices, will they get equal shares by the time they have gone right round the pizza — and if not, who will get more?' This is useful, of course, if you're familiar with the concept of 'sharing' a pizza."
Businesses

Treading the Fuzzy Line Between Game Cloning and Theft 235

eldavojohn writes "Ars analyzes some knockoffs and near-knockoffs in the gaming world that led to problems with the original developers. Jenova Chen, creator of Flower and flOw, discusses how he feels about the clones made of his games. Chen reveals his true feelings about the takedown of Aquatica (a flOw knockoff): 'What bothers me the most is that because of my own overreaction, I might have created a lot of inconvenience to the creator of Aquatica and interrupted his game-making. He is clearly talented, and certainly a fan of flOw. I hope he can continue creating video games, but with his own design.' The article also notes the apparent similarities between Zynga's Cafe World and Playfish's Restaurant City (the two most popular Facebook games). Is that cloning or theft? Should clones be welcomed or abhorred?"
The Almighty Buck

EA Flip-Flops On Battlefield: Heroes Pricing, Fans Angry 221

An anonymous reader writes "Ben Kuchera from Ars Technica is reporting that EA/DICE has substantially changed the game model of Battlefield: Heroes, increasing the cost of weapons in Valor Points (the in-game currency that you earn by playing) to levels that even hardcore players cannot afford, and making them available in BattleFunds (the in-game currency that you buy with real money). Other consumables in the game, such as bandages to heal the players, suffered the same fate, turning the game into a subscription or pay-to-play model if players want to remain competitive. This goes against the creators' earlier stated objectives of not providing combat advantage to paying customers. Ben Cousins, from EA/DICE, argued, 'We also frankly wanted to make buying Battlefunds more appealing. We have wages to pay here in the Heroes team and in order to keep a team large enough to make new free content like maps and other game features we need to increase the amount of BF that people buy. Battlefield Heroes is a business at the end of the day and for a company like EA who recently laid off 16% of their workforce, we need to keep an eye on the accounts and make sure we are doing our bit for the company.' The official forums discussion thread is full of angry responses from upset users, who feel this change is a betrayal of the original stated objectives of the game."
Space

Herschel Spectroscopy of Future Supernova 21

davecl writes "ESA's Herschel Space Telescope has released its first spectroscopic results. These include observations of VYCMa, a star 50 times as massive as the sun and soon to become a supernova, as well as a nearby galaxy, more distant colliding starburst galaxies and a comet in our own solar system. The spectra show more lines than have ever been seen in these objects in the far-infrared and will allow astronomers to work out the detailed chemistry and physics behind star and planet formation as well as the last stages of stellar evolution before VYCMa's eventual collapse into a supernova. More coverage is available at the Herschel Mission Blog, which I run."

Comment Re:No light pollution there (Score 2, Informative) 154

Your post got me curious if this was true or not (whether looking from the botttom of a well would allow one to see stars) as its much more intuitive to have the lens be the primary mechanism for telescope than simply the tube. I don't think it is. Snopes actually has an article on whether this is true and under what conditions could one even hypothesize it is true:

http://www.snopes.com/science/well.asp

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