I do. I've worked on VFX, CG and games for just over 15 years now. I ended up in the industry because of my knowledge of Perl (back in 1997). Yeah, go figure. As a skilled software engineer, however, I was a rare commodity at the time since I was willing to play in the realm of data modeling, databases, asset management, systems engineering, etc. Basically not the sexy stuff like writing a renderer. More building the machine to run the renderer on millions of frames of a movie. 'Natch.
It would seem to be a competitive field, but honestly, most of the resumes I've seen have not been very impressive. We have a hard time finding motivated, skilled candidates. People think it is all about CG and 3D. That is a small, important part. But by no means the end of it. If you have the chops (and you know if you do, confidence is a big part of this), then get your resume out there. (As a side note, get an English major, e.g, an excellent tech writer, to proofread your resume. Make it look nice and organized. Nothing turns me off more than a poorly organized resume. Find a good resume and emulate it).
You can target the usual suspects. Dreamworks, Pixar, Digital Domain, Weta, and EA. Stay through the credits of any CG or heavy VFX movie and you'll see all the names of all the companies you should be investigating. Check out Autodesk, The Foundry, PipelineFX, and other companies that write software for the CG industry.
Did I mention staying through the credits? I'm saying it again. You've seen the movie, honor the people who worked on it that you didn't spend the last couple hours seeing directly on the screen. It is not often in our world we can see how an individual contributed to a larger work in such a direct fashion.
As for spotlight tech, knowing Python is key. It is used by major tools in the industry like Maya, Nuke, and Katana. If you don't know it, learn it. It is also very helpful to know Linux (yes, command-line Linux). Learn all about queuing systems. Know your C and C++ (interfacing with third-party libraries from within Python can be highly useful).
Go to SIGGRAPH. It is in LA this year. I won't be going myself, but it is always a great networking opportunity. Attend interesting talks. Stay after and talk to the speakers. Ask interesting questions. Listen well. You might even get invited out to a dinner or a party. Do it. Listen more.
It will be all worth for the first time you see yourself credited on-screen. I still get all giddy when I think of Antz and my first movie credit as "TD Tools Programmer". So watch Antz, find that credit, and you'll know who I am... (No cheating using IMDB, really, go watch the movie).