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Comment Column Stabilization Assembly (Score 3, Interesting) 89

Long ago, worked for a company that sold chromatography columns. They came in various sizes, but the biggest were over a foot across and a few feet high. Fill it with chromatography medium which has density like water and now it's heavy.

Customers want a way to move these things, but if you just put it on casters it's tippy, and if it tips over it probably breaks and now you've got a broken column and a HUGE mess. So the casters were on a metal frame with a diameter of a couple of feet and the column in the middle, and the whole thing has to be safe for sterile environments so now we're talking stainless steel, and the list price for this thing ended up being in the thousands for, you know, a set of furniture casters.

We called it the "Column Stabilization Assembly" to try and take the edge the sticker shock.

Comment Tanks (Score 1) 59

Linux [...] is not a business at all. It's a bunch of RVs, yurts, tepees, and geodesic domes set up in a field and organized by consensus. The people who live there are making tanks. These are not old-fashioned, cash-iron Soviet tanks; these are more like the M1 tanks of the U.S. Army, made of space-age materials and jammed with sophisticated technology from one end to the other. But they are better than army tanks. They've been modified in such a way that they never, ever break down, are light and maneuverable enough to use on ordinary streets, and use no more fuel than a subcompact car. These tanks are being cranked out, on the spot, at a terrific pace, and a vast number of them are lined up along the edge of the road with keys in the ignition. Anyone who wants can simply climb into one and drive it away for free.

--Neal Stephenson, In the Beginning was the Command Line

Comment Re:What do you expect? (Score 4, Informative) 247

Does it really matter to you who the people who make your browser are like?

Yeah, it does.

I need those people to be, like, UI designers. People who know something about human factors and GUI design. The people designing the FireFox UI manifestly do not.

Separating the tabs from the pages is major lossage. I never used to think about tabs. I just clicked on them when I needed them. Now I have to go searching for them, and there is this nagging insecurity as to whether I've got the right one (especially when I'm closing a tab, which is my most common use case). They've taken something that used to be handled by unthinking eye-hand coordination and pushed it up to the cognitive levels of my brain, where it competes for my attention with what I'm actually trying to do (read content on the web).

I'm also aware that they've hollowed out the home icon to the point where it is difficult to target with the mouse, because it doesn't look like a solid object. Again, I didn't used to be "aware" of the home icon at all. It just sat there at the top of my screen and I clicked on it when I needed to. Now it's a problem. The forward and back arrows have the same problem, but I don't use them as much, so I don't care about them as much.

It seems like the designers have this idea that the browser should fade into the background so that the user can focus on web content. That's fine as a guiding principle, but they are sacrificing actual usability for an illusion of simplicity. By making the GUI actually, visually fade, they make the browser harder to use.

I'm about ready to start looking for another browser.

Comment 2,4-Dinitrophenol (DNP) (Score 4, Informative) 25

From https://en.wikipedia.org/wiki/...

DNP acts as a protonophore, allowing protons to leak across the inner mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient. In effect, part of the energy that is normally produced from cellular respiration is wasted as heat.

DNP was used extensively in diet pills from 1933 to 1938 [...]

The factor that limits ever-increasing doses of DNP is not a lack of ATP energy production, but rather an excessive rise in body temperature due to the heat produced [...]. Accordingly, DNP overdose will cause fatal hyperthermia, with body temperature rising to as high as 43.1 C (109.6 F) shortly before death.

In light of the adverse effects and fatal hyperthermia caused by DNP when it was used clinically, the dose was slowly titrated according to personal tolerance, which varies greatly. Concerns about dangerous side-effects and rapidly developing cataracts resulted in DNP being discontinued in the United States by the end of 1938. In 1938, the FDA included DNP in a list of drugs potentially so toxic that they should not be used even under a physician's supervision.

Comment This makes no sense (Score 2) 43

This makes no sense on multiple levels.

What they are trying to automate is the labor done by shoppers as they move products from shelves to shopping carts. But that labor is
- hard to automate from a robotics standpoint (unstructured problem domain)
- even harder to automate in terms of getting the shopper what they actually want (no apples; substitute canned beets y/n?)
- already free to the grocery store

What you need to do this is a grocery chain + robotics. The grocery chains won't do it because it cannibalizes their core business; the robotics companies won't do it because it is a hard problem with no clear ROI, and if a grocer and a robotics company did get together and do it why should Instacart get a cut?

It reminds me of the early days of the web, when everyone had an idea for a web site that would make them loads of money...if someone else would just build it for them.

Comment Re:Show of hands (Score 1) 11

My wife.
To get to homedepot.com, my wife types Home Depo into Google and then clicks on the top hit.
The top hit is always an ad.
Sometimes that ad links to homedepot.com
Sometimes that ad links to a malware site that locks up your browser and demands that you buy some "antivirus" product.
I finally manged to explain to her that Google ads go to whomever is currently paying Google the most money for your search terms.
You don't know who that is, so you should never click on a Google ad.

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