It should also be noted that these and other "designer" drugs are not very enjoyable. The reality is that all the "good" drugs (relatively harmless, few unpleasant side effects) are either illegal or heavily taxed and subject to production and distribution monopolies.
We've only scratched the surface of what's possible. You're right, many of the current "research chemicals" are worse than their natural counterparts. JWH is absolutely less fun and more harmful than THC. Whatever they're passing around on blotter these days is no match for real LSD.
But for that matter, LSD was an unknown research chemical once. And it's at least as good as any natural psychedelic. I have it on good authority that MXE, discussed in the article, is more enjoyable than Ketamine. At this point we don't know what the side effects are, but it's possible that it's safe.
There are receptors in our brain that we don't even know what they bind. The receptors that we do know the ligands of, have allosteric sites that could bind novel chemicals. The drugs we know of could be improved upon, we don't know until we try.
So yes, don't take "spice" or bath salts. But don't be surprised if something new and amazing comes out of these basement labs either.