Dava Newman, Apollo Professor of Aeronautics and Astronautics at MIT, warned that radiation is one of the biggest challenges to surviving and thriving in space. Once spacefarers pierce the atmosphere, they're subject to radiation from solar particles and cosmic rays, which increases the risk of cancer in the long term—and acute radiation sickness mid-mission.

• Ellen Pao: The combination of this belief that the internet was a bright, positive place and the very similar people who all shared that view ended up creating platforms that were designed and oriented around free speech.
• Harris: We cannot afford the advertising business model. The price of free is actually too high. It is literally destroying our society, because it incentivizes automated systems that have these inherent flaws.
• García: The real issue is that people don’t assign moral agency to algorithms. When shit goes sideways, you want someone to fucking shake a finger at and scream at.

A major challenge in keeping elections safe from cyberattacks, said Homeland Security's Christopher Krebs, has less to do with technology than with the way in which elections are held in the United States. Elections, even those held for the office of the president and Congress, are run by state and local governments, not by the federal government. That means each state and, frequently, individual localities have their own way to hold elections, implementing different technologies—from paper ballots to multiple kinds of voting machines, including direct-recording electronic (DRE) voting machines, some of which do not produce a paper trail and therefore are vulnerable to being hacked.

Krebs put the conundrum this way: “It is the responsibility of the states to administer elections. It is the responsibility of the Department of Homeland Security and the federal government to provide for the national security and national defense of this country. There is a discussion that needs to happen between those two things.”

A lot of people are taking money, almost literally, out of the pockets of musicians. These days, artists get a lot of their revenue from live performances, but middlemen are getting money that should go to them. And that's a major, major problem.

• We can provide an order-of-magnitude estimate. I find this helpful for an entire project. “We think it’s between five and nine months of work. We’ll know more when we answer these questions and finish that part of the complex work.” SWAGs might be good for these estimates.
• We can learn enough about the requirements to provide a reasonable estimate. That might require the team to workshop the stories to create an estimate with a small enough variation to set everyone’s expectations.
• We can estimate the requirements for a short time, such as a week or two of work. We might learn we didn’t estimate everything correctly. However, we are generally close enough that we don’t disappoint the people who asked for the estimate.

• Rothman goes into quite a bit of detail about when to use each way to estimate — and when to dig in your heels and refuse to offer a estimate.