The whole refrigerant treadmill is a an obvious grift and you can't convince me otherwise.
Every 10-20 years they (meaning a conglomerate of industry focus groups, big chem companies, and the government) declare that the Old, Commoditized Planet Destroying Refrigerants (OCPDR's) are too bad for the environment, but they've invented New Patented Miracle Refrigerant (NPMR) that is better. The NPMR also happens to be expensive, and it also "happens to be" incompatible with all the refrigerant systems out there, usually due to higher pressures or special lubricants, and typically, it's also a worse refrigerant in thermodynamic terms (there was a reason OCPDR became popular after all), making the systems to use it bigger and more expensive at minimum, and likely actually less efficient.
The government will announce a phase-out of the OCPDR and phase-in of the NPMR. The result is that the OCPDR prices will skyrocket through the roof after they are illegal to manufacture, so commodities speculators make a fortune on the OCPDR's for years into the future. Meanwhile the Big Chem companies have a guaranteed market for their NPMR, they spin off their OCPDR factories to the little guys and at first they are the only companies who know how to make it or have the patents to make the NPMR. And the entire HVAC industry will make a killing for the next 10+ years ripping out old, perfectly functional AC's and industrial cooling systems, simply because they are not compatible with NPMR and OCPDR is either unavailable or so expensive they are forced to upgrade.
After 10-15 years, the NPMR becomes the next Old Commoditized Planet Destroying Refrigerant and the cycle starts over. Once Big Chem isn't making as much as they used to, it's time to invent New Patented Miracle Refrigerant once again and get the government to mandate it. The whole cycle is very similar to the whole patented drug vs. generic drug treadmill.
Meanwhile, non-corrupt nations or applications outside regulation are simply switching to R290 and other hydrocarbon refrigerants, which has a global warming potential of only 3, better than practically any other refrigerant, and it's also extremely cheap and easy to manufacture, like, 10x cheaper than latest NPMR. Wildcat HVAC people in my area are using R290 to re-charge old R-22 systems, and they work just as well or better than they did on R-22, meanwhile having literally the best possible GWP available, and saving old, functional HVAC systems. But this is illegal in the US because R290 is not approved, and the official path is to either buy R-22 at $megamoney per pound, or replace the entire system with one compatible with NPMR (for now). Literally the only "problem" with R290 is that it's not patented, and anyone can make it, which doesn't make Dow Chemical or DuPont any money at all, which is why it will never be adopted in the US.