I'm left-handed. In school, I found that my writing tended to become illegible rather quickly, because of having to `push' rather than `pull' across the paper.
One day, I was browsing in a bookshop when I noticed a facsimile of some of Leonardo da Vinci's notes. Now, everyone knows that he wrote his personal notes backwards, and writing backwards is often a sign of left-handedness. And since da Vinci hacked on just about everything else going in Renaissance Italy, I wondered whether he might have hacked his own handwriting for ease of use. And he must have had to write to other people occasionally --- he couldn't ALWAYS have written backwards.
So I bought the book and with a mirror and a magnifying-glass figured out how he formed his letters. And I found that actually, his handwriting is very easy when writing left-to-right. I think that most of the ease comes from replacing difficult `pushed' curves with straight lines wherever possible. For example, using a small capital N rather than n, using a small captial A rather than a, forming g like a modern cursive z, and so on. Other improvements appear to have been made for speed, such as not dotting i or j. Other decisions appear to have been made to slow the hand down briefly but regularly; for example, writing capitals large, and with curves.
So I adopted his ways of forming letters, and found that I could write quicker, more fluidly, and without much of the hand-cramp from which I used to suffer. A decade later, I still use his handwriting.