Comment Need more info.. (Score 4, Informative) 460
Here is an excellent resource (at least last time I checked and it has been awhile, they used to be called macosxlabs.org).
http://www.macenterprise.org/
As far as tools, the built in tools are very good. A third party tool that can be very useful for bootable drive images is Carbon Copy Cloner. When you say large, do you mean hundreds or thousands, or less? It will definitely change things for you. I think that you will be surprised by both the ease of the transition, and the things that should be easy that are not. Really I don't know how we can help you unless you have specific areas where you are interested in learning solutions (and I don't say that to be a jerk, I'll try to answer questions where I can). How many servers? Directory Server? File Sharing? Exchange Server/POP/IMAP? Calendaring? Centralized home directories? Budget per user? Of course there are cool things that cost money and are not really needed, and hard things that are cheap but work well once set up etc. I would help more, but I don't know where to start... take a look at the link above, and ask questions as you get a better idea of he scope