Unfortunately, anybody savvy enough to know about and install Google Frame isn't running IE anyway...
Google wave will change that. When people start migrating from Facebook (already a privacy scare for many, not to mention the "help" the media is giving), and even email, to wave -- Google will slap up some nice "propositions", such as "Oops! You're not running the Google frame. Click here to see how you can improve your wave experience!", or better yet "Oops! You're not using Google Chrome! ..." -- click, smack, and done. Shortly thereafter netbook manufacturers will start shipping their hardware with Chrome OS, which fits like a glove to wave, youtube -- you name it. It doesn't take a genious to see how Google will make all this fit together. You might be wondering "why Google frame and not Chrome right away?" -- easy, it's their wave... wave (hah)... to surf on that is. You see if wave is slow, it won't catch on, but with the Google frame it won't be, and people don't need to leave their comfortable IE environment at all. Hence Google frame is just a stepping stone towards promoting wave, and it will be abandoned in due time. Basically: anybody who ever visits a Google owned page with IE will have a very, very easy way of installing the Google frame. Most people will probably not even know what hit them -- and they wouldn't even care if they did.