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Submission + - Watching Drug Resistance Develop in Vivo

nursegirl writes: As the spread of multi-drug resistant bacteria like MRSA and the new XDR-TB (extremely drug resistant tuberculosis) becomes a growing concern throughout the world, a team of scientists has been able to learn how bacteria evolves in vivo as a response to vancomycin and other antibiotics.

The team isolated S. aureus bacteria intermittently through a patient's antibiotic therapy and sequenced the genome of the bacterium multiple times. The results demonstrated 35 mutations in 31 locations as the bacteria evolved from vancomycin-susceptible to vancomycin-resistant.

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